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Atiprimod dihydrochloride

CAS No. 130065-61-1

Atiprimod dihydrochloride( SKF 106615 | Azaspirane )

Catalog No. M11208 CAS No. 130065-61-1

Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Atiprimod dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
  • Description
    Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways; efficaciously inhibits the proliferation of FDCP-EpoR JAK2 (V617F) (IC50=0.42 uM) and SET-2 cells (IC50= 0.53 uM); blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells (MM.1S, U266, and RPMI8226 MM cell lines IC50=0.5-1.25 uM), significantly inhibits production of IL-6 and inflammation in rat arthritis and autoimmune animal models.Brain Cancer Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SKF 106615 | Azaspirane
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK
  • Research Area
    Cancer
  • Indication
    Brain Cancer

Chemical Information

  • CAS Number
    130065-61-1
  • Formula Weight
    409.524
  • Molecular Formula
    C22H46Cl2N2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCC(CC1)(CCC)CCC21CCN(CCCN(CC)CC)C2.[H]Cl.[H]Cl
  • Chemical Name
    3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Quintás-Cardama A, et al. Invest New Drugs. 2011 Oct;29(5):818-26. 2. Neri P, et al. Leukemia. 2007 Dec;21(12):2519-26. 3. Hamasaki M, et al. Blood. 2005 Jun 1;105(11):4470-6. 4. Choudhari SR, et al. Mol Cancer Ther. 2007 Jan;6(1):112-21.
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